In vivo attenuation of experimentally-induced oxidative stress by common African vegetable (Corchorus olitorius)

Despite decades of study, the significance free radicals' function in organ damage remains questionable and is still a significant problem diagnosis many diseases. Therefore, goal current investigation was to determine whether Corchorus olitorius leaves could reduce oxidative stress caused by potassium bromate (KBrO3). Twenty-four rats were put into groups A, B, C, D. Group A received distilled water as control. Animals C D additionally given 100 200 mg/kg body weight C. olitorius, respectively, addition KBrO3 on daily basis for 28 days. The animals sacrificed while being gently sedated with diethyl ether blood, heart, liver, kidneys collected. results showed that decreased plasma, hepatic, renal, cardiac CAT, SOD, GPx activities well GSH concentrations, but raised MDA levels, compared control group. Rats extract from at doses weight, dose comparable those observed These treatments resulted increases antioxidant levels (except GPx) decrease their plasma tissues. study increased enzymes leading stress. This effect attenuated Olitorius demonstrating its protective KBrO3-induced stress.\